Selected Tool: SELECT GENE

Gene Details of YAP1 YML007W

This page lists all of the phenotypes in which the selected gene occurs. A summary of the GO slim terms for the selected gene is also shown.
sgd_id.Standard_gene_nameFeature_NameFeature_Type.Feature_qualifierParent_feature_name
S000004466YAP1YML007WORFVerifiedchromosome 13

Description Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus

This gene is present in 25 Phenotypes


Show/Hide +/- Phenotypes
LinkPhenotypeCitation
1
oxidative stress resistance: decreased hydrogen peroxide (5 mM)Auesukaree C, et al. (2009) Genome-wide identification of genes involved in tolerance to various environmental stresses in Saccharomyces cerevisiae. J Appl Genet 50(3):301-310
2
affected redox environment - more oxidized cytosol "nil, tested DTT treatment"Ayer A, et al. (2012) A genome-wide screen in yeast identifies specific oxidative stress genes required for the maintenance of sub-cellular redox homeostasis. PLoS One 7(9):e44278
3
resistance to chemicals: decreased CTBT (4 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine) no growth on YPD plus 4 ug/ml CTBTBatova M, et al. (2010) Chemogenomic and transcriptome analysis identifies mode of action of the chemosensitizing agent CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine). BMC Genomics 11():153
4
high susceptibility 1.2 or 1.5_mg/L mancozebDias PJ, et al. (2010) Insights into the mechanisms of toxicity and tolerance to the agricultural fungicide mancozeb in yeast, as suggested by a chemogenomic approach. OMICS 14(2):211-27
5
resistance to chemicals: decreased S-{2-[4-(dihydroxyarsino)phenylamino]-2-oxoethyl}-glutathioneDilda PJ, et al. (2005) Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. J Natl Cancer Inst 97(20):1539-47
6
sensitive arsenic trioxideDilda PJ, et al. (2008) Insight into the selectivity of arsenic trioxide for acute promyelocytic leukemia cells by characterizing Saccharomyces cerevisiae deletion strains that are sensitive or resistant to the metalloid. Int J Biochem Cell Biol 40(5):1016-29
7
resistance (suppress the accumulation of mutations that inactivate the CAN1 gene canavanineHuang ME, et al. (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100(20):11529-34
8
resistance to chemicals: decreased camptothecin (43 uM)Kapitzky L, et al. (2010) Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol 6():451
9
resistance to chemicals: decreased cycloheximide (0.18 uM)Kapitzky L, et al. (2010) Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol 6():451
10
resistance to chemicals: decreased hydroxyurea (100 mM)Kapitzky L, et al. (2010) Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol 6():451
11
resistance to chemicals: decreased sirolimus (0.003 uM) sirolimus is rapamycinKapitzky L, et al. (2010) Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol 6():451
12
resistance to chemicals: decreased tunicamycin (0.6 uM)Kapitzky L, et al. (2010) Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol 6():451
13
resistance to chemicals: increased fenpropimorph (16.5 uM)Kapitzky L, et al. (2010) Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol 6():451
14
Pointed strains alpha factorNarayanaswamy R, et al. (2006) Systematic profiling of cellular phenotypes with spotted cell microarrays reveals mating-pheromone response genes. Genome Biol 7(1):R6
15
resistance to chemicals: decreased L-1,4-dithiothreitol (16 mM)Rand JD and Grant CM (2006) The thioredoxin system protects ribosomes against stress-induced aggregation. Mol Biol Cell 17(1):387-401
16
resistance to chemicals: decreased cadmium dichloride (50 uM)Serero A, et al. (2008) Yeast genes involved in cadmium tolerance: Identification of DNA replication as a target of cadmium toxicity. DNA Repair (Amst) 7(8):1262-75
17
resistance to chemicals: decreased L-1,4-dithiothreitol (20 mM)Tan SX, et al. (2009) Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Biol Cell 20(5):1493-508
18
resistance to chemicals: decreased tunicamycin (6 ug/ml)Tan SX, et al. (2009) Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Biol Cell 20(5):1493-508
19
Sensitive Cumene HydroperoxideThorpe GW, et al. (2004) Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes. Proc Natl Acad Sci U S A 101(17):6564-9
20
Sensitive Diamide (thiol oxidizing agent)Thorpe GW, et al. (2004) Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes. Proc Natl Acad Sci U S A 101(17):6564-9
21
Sensitive Hydrogen Peroxide (H2O2)Thorpe GW, et al. (2004) Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes. Proc Natl Acad Sci U S A 101(17):6564-9
22
Sensitive Linoleic Acid 13HydroperoxideThorpe GW, et al. (2004) Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes. Proc Natl Acad Sci U S A 101(17):6564-9
23
resistance to chemicals: decreased acrolein (5 mM)Trotter EW, et al. (2006) Old yellow enzymes protect against acrolein toxicity in the yeast Saccharomyces cerevisiae. Appl Environ Microbiol 72(7):4885-92
24
Sensitive Hydrogen PeroxideTucker CL and Fields S (2004) Quantitative genome-wide analysis of yeast deletion strain sensitivities to oxidative and chemical stress. Comp Funct Genomics 5(3):216-24
25
Sensitive MenadioneTucker CL and Fields S (2004) Quantitative genome-wide analysis of yeast deletion strain sensitivities to oxidative and chemical stress. Comp Funct Genomics 5(3):216-24

Details of YAP1 YML007W from go_slim_mapping

GO_AspectGO_Slim_termGOID
ComponentcytoplasmGO:0005737
ComponentnucleusGO:0005634
FunctionDNA bindingGO:0003677
Functionnucleic acid binding transcription factor activityGO:0001071
Processresponse to chemicalGO:0042221
Processresponse to heatGO:0009408
Processresponse to oxidative stressGO:0006979
ProcesssignalingGO:0023052
Processtranscription from RNA polymerase II promoterGO:0006366