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Table shows phenotypes for 111 papers and 187 phenotypes (including only phenotypes with intersections)


1Anand VC, et al. (2009) Genome-wide analysis of AP-3-dependent protein transport in yeast. Mol Biol Cell 20(5):1592-604 PubMed
1 ) protein/peptide modification: decreased alkaline phosphatase (ALP) processing to mature form is decreased Pho8p (ALP)[Genes (54), Intersections (33)]
2 ) protein/peptide modification: decreased carboxypeptidase S (CPS) processing to mature form is decreased carboxypeptidase S[Genes (48), Intersections (34)]
2Andersen MP, et al. (2008) A Genetic Screen for Increased Loss of Heterozygosity in Saccharomyces cerevisiae. Genetics 179(3):1179-95 PubMed
1 ) chromosome/plasmid maintenance abnormal loss of heterozygosity[Genes (62), Intersections (1)]
3Ando A, et al. (2007) Identification and classification of genes required for tolerance to freeze-thaw stress revealed by genome-wide screening of Saccharomyces cerevisiae deletion strains. FEMS Yeast Res 7(2):244-53 PubMed
1 ) freeze-thaw resistance: decreased frozen at -25 deg C for 5 days, then thawed at 30 deg C for 15 min.[Genes (58), Intersections (18)]
2 ) oxidative stress resistance: decreased hydrogen peroxide (2 mM)[Genes (35), Intersections (19)]
3 ) resistance to chemicals: decreased Calcofluor White (8.2 uM)[Genes (34), Intersections (21)]
4Aouida M, et al. (2004) A genome-wide screen in Saccharomyces cerevisiae reveals altered transport as a mechanism of resistance to the anticancer drug bleomycin. Cancer Res 64(3):1102-9 PubMed
1 ) Sensitive to BLM Bleomycin (2.0 _g/ml)[Genes (207), Intersections (50)]
5Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 PubMed
1 ) telomere length: decreased[Genes (115), Intersections (5)]
6Auesukaree C, et al. (2009) Genome-wide identification of genes involved in tolerance to various environmental stresses in Saccharomyces cerevisiae. J Appl Genet 50(3):301-310 PubMed
1 ) heat sensitivity: increased elevated temperature (37 deg C)[Genes (178), Intersections (22)]
2 ) hyperosmotic stress resistance: decreased sodium chloride (1 M)[Genes (42), Intersections (4)]
3 ) resistance to chemicals: decreased ethanol (10%)[Genes (95), Intersections (20)]
4 ) resistance to chemicals: decreased methanol (16%)[Genes (55), Intersections (8)]
5 ) resistance to chemicals: decreased propan-1-ol (7%)[Genes (125), Intersections (21)]
7Barreto L, et al. (2011) A genomewide screen for tolerance to cationic drugs reveals genes important for potassium homeostasis in Saccharomyces cerevisiae. Eukaryot Cell 10(9):1241-50 PubMed
1 ) resistance to chemicals: decreased hygromycin B[Genes (202), Intersections (47)]
2 ) resistance to chemicals: decreased spermine[Genes (201), Intersections (46)]
8Batova M, et al. (2010) Chemogenomic and transcriptome analysis identifies mode of action of the chemosensitizing agent CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine). BMC Genomics 11():153 PubMed
1 ) resistance to chemicals: decreased CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine) no growth on YPD plus 2 ug/ml CTBT[Genes (33), Intersections (1)]
2 ) resistance to chemicals: decreased CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine) slow growth on YPD plus 2 ug/ml CTBT and no growth at 4 ug/ml[Genes (78), Intersections (10)]
9Bennett CB, et al. (2001) Genes required for ionizing radiation resistance in yeast. Nat Genet 29(4):426-34 PubMed
1 ) sensitive to gamma-irradiation gammairradiation[Genes (127), Intersections (24)]
10Blackburn AS and Avery SV (2003) Genome-wide screening of Saccharomyces cerevisiae to identify genes required for antibiotic insusceptibility of eukaryotes. Antimicrob Agents Chemother 47(2):676-81 PubMed
1 ) resistance to chemicals: decreased gentamycin C1 (64 512 ug/ml)[Genes (17), Intersections (1)]
11Bleackley MR, et al. (2011) High density array screening to identify the genetic requirements for transition metal tolerance in Saccharomyces cerevisiae. Metallomics 3(2):195-205 PubMed
1 ) metal resistance: decreased cobalt(2+) (2.5 mM CoCl2)[Genes (87), Intersections (14)]
2 ) metal resistance: decreased manganese(2+) (4 mM MnCl2)[Genes (66), Intersections (17)]
3 ) metal resistance: decreased nickel(2+) (3 mM NiCl2)[Genes (46), Intersections (10)]
4 ) metal resistance: decreased zinc(2+) (7 mM ZnCl2)[Genes (77), Intersections (30)]
12Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501 PubMed
1 ) secreted strong-to-moderate levels of carboxypeptidase Y Screen for secretion of CPY into the medium[Genes (148), Intersections (55)]
13Botet J, et al. (2007) A Chemogenomic Screening of Sulfanilamide-Hypersensitive Saccharomyces cerevisiae Mutants Uncovers ABZ2, the Gene Encoding a Fungal Aminodeoxychorismate Lyase. Eukaryot Cell 6(11):2102-11 PubMed
1 ) resistance to chemicals: decreased sulfanilamide (0.2 mg/ml) SMM liquid medium[Genes (112), Intersections (25)]
14Cai H, et al. (2006) Genomewide Screen Reveals a Wide Regulatory Network for Di/Tripeptide Utilization in Saccharomyces cerevisiae. Genetics 172(3):1459-76 PubMed
1 ) nutrient utilization: decreased His-Leu cultured in minimal medium containing histidine, lysine, uracil and tryptophan decreased ability to utilize the His-Leu dipeptide resulting in poor growth relative to the wildtype control[Genes (57), Intersections (1)]
2 ) protein/peptide distribution: abnormal Ptr2p-GFP[Genes (44), Intersections (2)]
3 ) toxin resistance: increased Ala-Eth (0.1 uM) cultured in minimal medium containing histidine, leucine, lysine and uracil decreased sensitivity in toxic dipeptide halo assay[Genes (57), Intersections (1)]
4 ) utilization of nitrogen source: absent allantoin cultured in minimal medium containing histidine, leucine, lysine and uracil[Genes (108), Intersections (6)]
15Chang M, et al. (2002) A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A 99(26):16934-9 PubMed
1 ) resistance to chemicals: decreased methyl methanesulfonate (0.035%)[Genes (103), Intersections (24)]
16Chasse SA, et al. (2006) Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae. Eukaryot Cell 5(2):330-46 PubMed
1 ) altered pheromone signaling phenotype alphafactor yeast pheromone[Genes (90), Intersections (1)]
17Chen Y, et al. (2005) Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Cancer Res 3(12):669-77 PubMed
1 ) resistance to chemicals: decreased tunicamycin (1 ug/ml)[Genes (35), Intersections (1)]
18Cheng V, et al. (2007) Genome-Wide Screen for Oxalate-Sensitive Mutants of Saccharomyces cerevisiae. Appl Environ Microbiol 73(18):5919-27 PubMed
1 ) resistance to chemicals: decreased oxalic acid (30 mM)[Genes (26), Intersections (5)]
19Corbacho I, et al. (2005) A genome-wide screen for Saccharomyces cerevisiae nonessential genes involved in mannosyl phosphate transfer to mannoprotein-linked oligosaccharides. Fungal Genet Biol 42(9):773-90 PubMed
1 ) genes involved in mannosyl phosphate transfer to mannoprotein-linked oligosaccha low dye binding (ldb) phenotype[Genes (194), Intersections (68)]
20Daniel JA, et al. (2006) Diverse functions of spindle assembly checkpoint genes in Saccharomyces cerevisiae. Genetics 172(1):53-65 PubMed
1 ) chromosome/plasmid maintenance: abnormal diploid bimater (BiM) assay increased frequency of mitotic chromosome loss[Genes (78), Intersections (1)]
21Davis-Kaplan SR, et al. (2004) Genome-wide analysis of iron-dependent growth reveals a novel yeast gene required for vacuolar acidification. J Biol Chem 279(6):4322-9 PubMed
1 ) vegetative growth: decreased low iron level in media[Genes (15), Intersections (6)]
22de Castro PA, et al. (2011) Molecular Characterization of Propolis-Induced Cell Death in Saccharomyces cerevisiae. Eukaryot Cell 10(3):398-411 PubMed
1 ) resistance to chemicals: decreased propolis extract (0.5%)[Genes (138), Intersections (5)]
23De Filippi L, et al. (2007) Membrane stress is coupled to a rapid translational control of gene expression in chlorpromazine-treated cells. Curr Genet 52(3-4):171-85 PubMed
1 ) resistance to chemicals: decreased chlorpormazine (20 micro M)[Genes (40), Intersections (2)]
24Desmoucelles C, et al. (2002) Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid. J Biol Chem 277(30):27036-44 PubMed
1 ) resistance to chemicals: decreased mycophenolic acid (30-100 ug/ml)[Genes (64), Intersections (2)]
2 ) resistance to chemicals: decreased mycophenolic acid (30-100 ug/ml) hypersensitive[Genes (37), Intersections (3)]
25Dias PJ, et al. (2010) Insights into the mechanisms of toxicity and tolerance to the agricultural fungicide mancozeb in yeast, as suggested by a chemogenomic approach. OMICS 14(2):211-27 PubMed
1 ) high susceptibility 1.2 or 1.5_mg/L mancozeb[Genes (286), Intersections (57)]
26Dilda PJ, et al. (2005) Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. J Natl Cancer Inst 97(20):1539-47 PubMed
1 ) resistance to chemicals: decreased S-{2-[4-(dihydroxyarsino)phenylamino]-2-oxoethyl}-glutathione[Genes (87), Intersections (2)]
27Dilda PJ, et al. (2008) Insight into the selectivity of arsenic trioxide for acute promyelocytic leukemia cells by characterizing Saccharomyces cerevisiae deletion strains that are sensitive or resistant to the metalloid. Int J Biochem Cell Biol 40(5):1016-29 PubMed
1 ) sensitive arsenic trioxide[Genes (341), Intersections (37)]
28Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53 PubMed
1 ) mitochondrial morphology: abnormal morphology is somewhat affected; a fraction of cells exhibit wild-type mitochondrial morphology[Genes (83), Intersections (12)]
2 ) respiratory growth: absent glycerol carbon source[Genes (340), Intersections (39)]
3 ) respiratory growth: decreased rate glycerol carbon source[Genes (63), Intersections (1)]
29Dos Santos SC and Sa-Correia I (2011) A genome-wide screen identifies yeast genes required for protection against or enhanced cytotoxicity of the antimalarial drug quinine. Mol Genet Genomics 286(5-6):333-46 PubMed
1 ) resistance to chemicals: decreased quinine (1.5 g/L) hyper-susceptible mutant; fails to grow in the presence of 1.5 g/l quinine[Genes (102), Intersections (16)]
2 ) resistance to chemicals: decreased quinine (1.5 g/L) mutant grows slowly in the presence of 1.5 g/l quinine[Genes (175), Intersections (3)]
30Eide DJ, et al. (2005) Characterization of the yeast ionome: a genome-wide analysis of nutrient mineral and trace element homeostasis in Saccharomyces cerevisiae. Genome Biol 6(9):R77 PubMed
1 ) mineral accumulation decreacing by more than 2.5 standard deviations from the yeast ionome Co[Genes (62), Intersections (1)]
2 ) mineral accumulation decreacing by more than 2.5 standard deviations from the yeast ionome K[Genes (39), Intersections (1)]
3 ) mineral accumulation decreacing by more than 2.5 standard deviations from the yeast ionome Mg[Genes (108), Intersections (1)]
4 ) mineral accumulation decreacing by more than 2.5 standard deviations from the yeast ionome Ni[Genes (124), Intersections (5)]
5 ) mineral accumulation decreacing by more than 2.5 standard deviations from the yeast ionome P[Genes (68), Intersections (1)]
6 ) mineral accumulation decreacing by more than 2.5 standard deviations from the yeast ionome Se[Genes (103), Intersections (5)]
7 ) mineral accumulation increasing by more than 2.5 standard deviations from the yeast ionome Ca[Genes (66), Intersections (4)]
8 ) mineral accumulation increasing by more than 2.5 standard deviations from the yeast ionome Cu[Genes (93), Intersections (1)]
9 ) mineral accumulation increasing by more than 2.5 standard deviations from the yeast ionome Mn[Genes (98), Intersections (5)]
10 ) mineral accumulation increasing by more than 2.5 standard deviations from the yeast ionome S[Genes (102), Intersections (3)]
31Endo A, et al. (2008) Genome-wide screening of the genes required for tolerance to vanillin, which is a potential inhibitor of bioethanol fermentation, in Saccharomyces cerevisiae. Biotechnol Biofuels 1(1):3 PubMed
1 ) Sensitivity 5 mM vanillin[Genes (76), Intersections (2)]
32Enyenihi AH and Saunders WS (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54 PubMed
1 ) sporulation: absent[Genes (107), Intersections (2)]
33Fei W, et al. (2008) Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae. Eukaryot Cell 7(2):401-14 PubMed
1 ) resistance to chemicals: decreased lovastatin (150 ug/ml)[Genes (56), Intersections (4)]
34Fell GL, et al. (2011) Identification of yeast genes involved in k homeostasis: loss of membrane traffic genes affects k uptake. G3 (Bethesda) 1(1):43-56 PubMed
1 ) chemical compound accumulation: decreased rubidium(1+) Rb+ influx is a measure of K+ influx[Genes (41), Intersections (15)]
2 ) protein/peptide distribution: abnormal CPY is secreted rather than retained in the cell, and this phenotype is suppressed by supplementation with 500 mM KCl Prc1p (CPY)[Genes (10), Intersections (6)]
3 ) resistance to chemicals: decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is not suppressed by supplementation with 500 mM KCl[Genes (57), Intersections (11)]
4 ) resistance to chemicals: decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl[Genes (76), Intersections (9)]
5 ) resistance to chemicals: decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 500 mM KCl[Genes (23), Intersections (1)]
35Fleming JA, et al. (2002) Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341. Proc Natl Acad Sci U S A 99(3):1461-6 PubMed
1 ) resistance to chemicals: decreased bortezomib (260 uM) Similar results were seen with PS-519 (8 uM)[Genes (52), Intersections (1)]
36Freimoser FM, et al. (2006) Systematic screening of polyphosphate (poly P) levels in yeast mutant cells reveals strong interdependence with primary metabolism. Genome Biol 7(11):R109 PubMed
1 ) chemical compound accumulation: abnormal polyphosphate[Genes (252), Intersections (7)]
37Fujita K, et al. (2006) The genome-wide screening of yeast deletion mutants to identify the genes required for tolerance to ethanol and other alcohols. FEMS Yeast Res 6(5):744-50 PubMed
1 ) sensitivity to 1-pentanol 0.5% 1pentanol[Genes (48), Intersections (15)]
2 ) sensitivity to 1-propanol 4% 1propanol[Genes (122), Intersections (26)]
3 ) sensitivity to ethanol 10% ethanol[Genes (137), Intersections (25)]
38Gatbonton T, et al. (2006) Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet 2(3):e35 PubMed
1 ) Affected Telomere Length nil[Genes (146), Intersections (7)]
39Guerra L, et al. (2011) Bacterial genotoxin triggers FEN1-dependent RhoA activation, cytoskeleton remodeling and cell survival. J Cell Sci 124(Pt 16):2735-42 PubMed
1 ) Hypersensitivity cytolethal distending toxins genotoxin[Genes (78), Intersections (2)]
40Gupta SS, et al. (2003) Antifungal activity of amiodarone is mediated by disruption of calcium homeostasis. J Biol Chem 278(31):28831-9 PubMed
1 ) enhanced sensitivity amiodarone[Genes (35), Intersections (1)]
41Gustavsson M and Ronne H (2008) Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast. RNA 14(4):666-74 PubMed
1 ) resistance to chemicals: decreased 5-fluorouracil (15 ug/ml)[Genes (138), Intersections (7)]
42Gustavsson M, et al. (2008) Functional genomics of monensin sensitivity in yeast: implications for post-Golgi traffic and vacuolar H(+)-ATPase function. Mol Genet Genomics 280(3):233-48 PubMed
1 ) protein/peptide modification: decreased reduced processing of Prc1p to mature form carboxypeptidase Y[Genes (21), Intersections (2)]
2 ) protein/peptide modification: decreased monensin A (50 uM) reduced processing of Prc1p to mature form; processing is further reduced in the presence of monensin carboxypeptidase Y[Genes (17), Intersections (2)]
3 ) resistance to chemicals: decreased monensin A (50 uM) hypersensitive[Genes (32), Intersections (14)]
43Hancock LC, et al. (2006) Genomic analysis of the Opi- phenotype. Genetics 173(2):621-34 PubMed
1 ) chemical compound excretion: increased inositol synthetic medium lacking inositol and choline Opi- phenotype; overproduction and excretion of inositol in the absence of inositol and choline[Genes (90), Intersections (14)]
44Hazelwood LA, et al. (2010) Involvement of Vacuolar Sequestration and Active Transport in Tolerance of Saccharomyces cerevisiae to Hop Iso-{alpha}-Acids. Appl Environ Microbiol 76(1):318-28 PubMed
1 ) growth inhibition Hop Iso{alpha}Acids[Genes (20), Intersections (21)]
45Hellauer K, et al. (2005) Large-scale analysis of genes that alter sensitivity to the anticancer drug tirapazamine in Saccharomyces cerevisiae. Mol Pharmacol 68(5):1365-75 PubMed
1 ) resistance to chemicals: decreased tirapazamine (200 uM) hypersensitive relative to wildtype[Genes (55), Intersections (15)]
46Herst PM, et al. (2008) Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits. FEMS Yeast Res 8(6):897-905 PubMed
1 ) low Plasma Membrane Electron Transport Assay for PMET[Genes (79), Intersections (16)]
47Heuck S, et al. (2010) Genome-wide analysis of caesium and strontium accumulation in Saccharomyces cerevisiae. Yeast 27(10):817-35 PubMed
1 ) radionuclide accumulation Caesium (Cs(+)) and or Strontium (Sr(2+))[Genes (212), Intersections (26)]
48Huang B, et al. (2008) A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae. RNA 14(10):2183-94 PubMed
1 ) toxin resistance: increased K. lactis zymocin (killer eclipse assay)|full resistance[Genes (25), Intersections (1)]
49Huang ME, et al. (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100(20):11529-34 PubMed
1 ) resistance (suppress the accumulation of mutations that inactivate the CAN1 gene canavanine[Genes (33), Intersections (1)]
50Irwin B, et al. (2005) Retroviruses and yeast retrotransposons use overlapping sets of host genes. Genome Res 15(5):641-54 PubMed
1 ) transposable element transposition: decreased Ty3[Genes (66), Intersections (2)]
51Jorgensen P, et al. (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297(5580):395-400 PubMed
1 ) cell size: decreased mutant is among the smallest 5% of haploid deletion strains[Genes (190), Intersections (12)]
2 ) cell size: increased mutant is among the largest 5% of haploid deletion strains[Genes (200), Intersections (28)]
52Kanki T, et al. (2009) A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell 20(22):4730-8 PubMed
1 ) autophagy: absent autophagy assayed by delivery of cytoplasmic Pho8p to vacuole|cvt pathway is also blocked[Genes (8), Intersections (2)]
53Kapitzky L, et al. (2010) Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol 6():451 PubMed
1 ) resistance to chemicals: decreased bleomycin (3.2 uM)[Genes (288), Intersections (2)]
2 ) resistance to chemicals: decreased camptothecin (43 uM)[Genes (226), Intersections (1)]
3 ) resistance to chemicals: decreased hydroxyurea (100 mM)[Genes (210), Intersections (1)]
4 ) resistance to chemicals: decreased methyl methanesulfonate (1772 uM)[Genes (187), Intersections (3)]
5 ) resistance to chemicals: decreased tunicamycin (0.6 uM)[Genes (182), Intersections (1)]
54Kawahata M, et al. (2006) Yeast genes involved in response to lactic acid and acetic acid: acidic conditions caused by the organic acids in Saccharomyces cerevisiae cultures induce expression of intracellular metal metabolism genes regulated by Aft1p. FEMS Yeast Res 6(6):924-36 PubMed
1 ) Sensitivity to acids Acetic Acid[Genes (217), Intersections (56)]
2 ) Sensitivity to acids Hydrochloric Acid[Genes (172), Intersections (62)]
3 ) Sensitivity to acids Lactic Acid[Genes (128), Intersections (46)]
55Kitagawa T, et al. (2007) Genome-Wide Analysis of Cellular Response to Bacterial Genotoxin CdtB in Yeast. Infect Immun 75(3):1393-402 PubMed
1 ) altered phenotype transformation with cytolethal distending toxins[Genes (61), Intersections (7)]
56Kitagawa T, et al. (2011) Identification of genes that enhance cellulase protein production in yeast. J Biotechnol 151(2):194-203 PubMed
1 ) enhanced endoglucanase activity endoglucanase gene[Genes (55), Intersections (6)]
57Kushner DB, et al. (2003) Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus. Proc Natl Acad Sci U S A 100(26):15764-9 PubMed
1 ) RNA virus expression enhanced Strain transformed to express Brome mosaic virus proteins[Genes (39), Intersections (1)]
58Kwak YS, et al. (2011) Saccharomyces cerevisiae Genome-Wide Mutant Screen for Sensitivity to 2,4-Diacetylphloroglucinol, an Antibiotic Produced by Pseudomonas fluorescens. Appl Environ Microbiol 77(5):1770-6 PubMed
1 ) resistance to chemicals: decreased 2,4-diacetylphloroglucinol[Genes (58), Intersections (5)]
59Landstetter N, et al. (2010) Functional genomics of drug-induced ion homeostasis identifies a novel regulatory crosstalk of iron and zinc regulons in yeast. OMICS 14(6):651-63 PubMed
1 ) resistance to chemicals: decreased pyrrolidine dithiocarbamate (20 uM)[Genes (135), Intersections (45)]
60Lesuisse E, et al. (2005) Genome-wide screen for genes with effects on distinct iron uptake activities in Saccharomyces cerevisiae. Genetics 169(1):107-22 PubMed
1 ) Altered uptake of Iron High iron (ferrioxamine B) uptake[Genes (75), Intersections (2)]
61Liao C, et al. (2007) Genomic Screening in Vivo Reveals the Role Played by Vacuolar H+ ATPase and Cytosolic Acidification in Sensitivity to DNA-Damaging Agents Such as Cisplatin. Mol Pharmacol 71(2):416-25 PubMed
1 ) resistance to chemicals: decreased cisplatin (250 ug/ml)[Genes (72), Intersections (12)]
62Linderholm AL, et al. (2008) Identification of genes affecting hydrogen sulfide formation in Saccharomyces cerevisiae. Appl Environ Microbiol 74(5):1418-27 PubMed
1 ) colony color darker (production of hydrogen sulfide) nil[Genes (88), Intersections (2)]
63Lockshon D, et al. (2007) The sensitivity of yeast mutants to oleic Acid implicates the peroxisome and other processes in membrane function. Genetics 175(1):77-91 PubMed
1 ) resistance to chemicals: decreased oleate (0.1%)[Genes (137), Intersections (3)]
64Loukin SH, et al. (2007) Lipid perturbations sensitize osmotic down-shock activated Ca2+ influx, a yeast "deletome" analysis. FASEB J 21(8):1813-20 PubMed
1 ) deletants hypersensitive to osmotic down shock( causes influx of Ca2) top 50 strong responders[Genes (50), Intersections (7)]
65Luban C, et al. (2005) Systematic screening of nuclear encoded proteins involved in the splicing metabolism of group II introns in yeast mitochondria. Gene 354:72-9 PubMed
1 ) Proteins that assist group II splicing Proteins that assist group II splicing[Genes (109), Intersections (9)]
66Manikova D, et al. (2012) Selenium toxicity toward yeast as assessed by microarray analysis and deletion mutant library screen: a role for DNA repair. Chem Res Toxicol 25(8):1598-608 PubMed
1 ) resistance to chemicals: decreased selenium(2+) (0.05 mM disodium selenite)[Genes (38), Intersections (5)]
67Martin DC, et al. (2011) New Regulators of a High Affinity Ca2+ Influx System Revealed through a Genome-wide Screen in Yeast. J Biol Chem 286(12):10744-54 PubMed
1 ) exhibited altered Ca2+ uptake in YPD nil[Genes (178), Intersections (46)]
68McLaughlin JE, et al. (2009) A genome-wide screen in Saccharomyces cerevisiae reveals a critical role for the mitochondria in the toxicity of a trichothecene mycotoxin. Proc Natl Acad Sci U S A 106(51):21883-8 PubMed
1 ) resistance to chemicals: increased trichothecene (4 uM)[Genes (133), Intersections (10)]
69Merz S and Westermann B (2009) Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Genome Biol 10(9):R95 PubMed
1 ) mitochondrial genome maintenance: abnormal nucleoids are absent in at least 95% of cells after cytoduction[Genes (15), Intersections (1)]
2 ) respiratory growth: absent glycerol carbon source[Genes (292), Intersections (26)]
70Mira NP, et al. (2009) The RIM101 pathway has a role in Saccharomyces cerevisiae adaptive response and resistance to propionic acid and other weak acids. FEMS Yeast Res 9(2):202-16 PubMed
1 ) acid pH resistance: decreased propionic acid (20 mM)[Genes (268), Intersections (15)]
71Mira NP, et al. (2010) Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid. Microb Cell Fact 9(1):79 PubMed
1 ) highly susceptible acetic acid 70 mM at pH 4.5[Genes (315), Intersections (29)]
72Mollapour M, et al. (2004) Screening the yeast deletant mutant collection for hypersensitivity and hyper-resistance to sorbate, a weak organic acid food preservative. Yeast 21(11):927-46 PubMed
1 ) Sensitivity YPD plus 2 mM sorbate pH 4.5[Genes (231), Intersections (58)]
73Narayanaswamy R, et al. (2006) Systematic profiling of cellular phenotypes with spotted cell microarrays reveals mating-pheromone response genes. Genome Biol 7(1):R6 PubMed
1 ) Arrest and Shmoo Defective (ASD) Strains alpha factor[Genes (30), Intersections (1)]
2 ) Elongated strains alpha factor[Genes (110), Intersections (3)]
74Ni L and Snyder M (2001) A genomic study of the bipolar bud site selection pattern in Saccharomyces cerevisiae. Mol Biol Cell 12(7):2147-70 PubMed
1 ) budding pattern: abnormal >50% of cells exhibited random budding pattern[Genes (74), Intersections (2)]
2 ) cell shape: abnormal round cell shape; moderate defect[Genes (47), Intersections (1)]
75Ohya Y, et al. (2005) High-dimensional and large-scale phenotyping of yeast mutants. Proc Natl Acad Sci U S A 102(52):19015-20 PubMed
1 ) morphological mutant 20 or more parameters disrupted with threshold 1.00E06[Genes (156), Intersections (18)]
76Outten CE, et al. (2005) Cellular factors required for protection from hyperoxia toxicity in Saccharomyces cerevisiae. Biochem J 388(Pt 1):93-101 PubMed
1 ) oxidative stress resistance: decreased dioxygen (100%) decreased growth in 100% oxygen atmosphere[Genes (70), Intersections (28)]
2 ) oxidative stress resistance: decreased hydrogen peroxide (2 mM) decreased growth in 2 mM H2O2[Genes (27), Intersections (14)]
3 ) oxidative stress resistance: decreased paraquat (0.5 mM) decreased growth in 0.5 mM paraquat[Genes (32), Intersections (9)]
4 ) oxidative stress resistance: decreased paraquat (0.5 mM) fails to grow in 0.5 mM paraquat[Genes (16), Intersections (2)]
77Page N, et al. (2003) A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin. Genetics 163(3):875-94 PubMed
1 ) Genes whose homozygous diploid deletion causes hypersensitivity K1 killer toxin[Genes (64), Intersections (4)]
78Perrone GG, et al. (2005) Genetic and environmental factors influencing glutathione homeostasis in Saccharomyces cerevisiae. Mol Biol Cell 16(1):218-30 PubMed
1 ) chemical compound excretion: increased glutathione SD medium[Genes (268), Intersections (50)]
2 ) resistance to chemicals: decreased 1,4-dithiothreitol (12 mM)[Genes (74), Intersections (19)]
3 ) respiratory growth: absent glycerol[Genes (93), Intersections (9)]
79Proszynski TJ, et al. (2005) A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. Proc Natl Acad Sci U S A 102(50):17981-6 PubMed
1 ) protein/peptide distribution: abnormal vacuolar staining is absent but delivery to the plasma membrane is normal or enhanced Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p)[Genes (60), Intersections (10)]
80Rand JD and Grant CM (2006) The thioredoxin system protects ribosomes against stress-induced aggregation. Mol Biol Cell 17(1):387-401 PubMed
1 ) resistance to chemicals: decreased L-1,4-dithiothreitol (32 mM)[Genes (174), Intersections (60)]
81Reeder NL, et al. (2011) Zinc pyrithione inhibits yeast growth through copper influx and inactivation of iron-sulfur proteins. Antimicrob Agents Chemother 55(12):5753-60 PubMed
1 ) Sensitive Zinc Chloride[Genes (20), Intersections (26)]
82Rodriguez-Porrata B, et al. (2012) Sip18 hydrophilin prevents yeast cell death during desiccation stress. J Appl Microbiol 112(3):512-25 PubMed
1 ) desiccation resistance: decreased less than 10% viability after dehydration stress[Genes (117), Intersections (5)]
83Ruotolo R, et al. (2008) Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome Biol 9(4):R67 PubMed
1 ) metal resistance: decreased cadmium(2+) (50 uM)[Genes (79), Intersections (50)]
2 ) metal resistance: decreased nickel(2+) (2.5 mM)[Genes (81), Intersections (50)]
84Sambade M, et al. (2005) A genomic screen for yeast vacuolar membrane ATPase mutants. Genetics 170(4):1539-51 PubMed
1 ) alkaline pH resistance: decreased calcium dichloride (60 mM) YPD|alkaline conditions (pH 7.5) growth defects at pH 7.5 in 60 mM calcium chloride - vma phenotype[Genes (49), Intersections (8)]
2 ) metal resistance: decreased zinc dichloride (4 mM)[Genes (10), Intersections (1)]
3 ) resistance to chemicals: decreased cyclosporin A (150 ug/ml)[Genes (14), Intersections (1)]
85Santos SC and Sa-Correia I (2009) Genome-Wide Identification of Genes Required for Yeast Growth Under Imatinib Stress: Vacuolar H(+)-ATPase Function Is an Important Target of This Anticancer Drug. OMICS 13(3):185-98 PubMed
1 ) Severe growth defect or significantly inhibited deletion strain Imatinib[Genes (51), Intersections (26)]
86Serero A, et al. (2008) Yeast genes involved in cadmium tolerance: Identification of DNA replication as a target of cadmium toxicity. DNA Repair (Amst) 7(8):1262-75 PubMed
1 ) resistance to chemicals: decreased cadmium dichloride (50 uM)[Genes (74), Intersections (11)]
87Serrano R, et al. (2004) Copper and iron are the limiting factors for growth of the yeast Saccharomyces cerevisiae in an alkaline environment. J Biol Chem 279(19):19698-704 PubMed
1 ) alkaline pH resistance: decreased pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units[Genes (118), Intersections (56)]
88Shuster A, et al. (2007) Alcohol-conferred hemolysis in yeast is a consequence of increased respiratory burden. FEMS Yeast Res 7(6):879-886 PubMed
1 ) MACH-Slowgrowers microbial alcohol conferred hemolysis[Genes (238), Intersections (22)]
89Suzuki T, et al. (2012) Lactic-acid stress causes vacuolar fragmentation and impairs intracellular amino-acid homeostasis in Saccharomyces cerevisiae. J Biosci Bioeng 113(4):421-30 PubMed
1 ) hypersensitivity 4.0% llactic acid (pH 2.8)[Genes (107), Intersections (43)]
90Szymanski KM, et al. (2007) The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology. Proc Natl Acad Sci U S A 104(52):20890-5 PubMed
1 ) lipid particle morphology: abnormal[Genes (59), Intersections (13)]
91Tan SX, et al. (2009) Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Biol Cell 20(5):1493-508 PubMed
1 ) resistance to chemicals: decreased L-1,4-dithiothreitol (20 mM)[Genes (85), Intersections (10)]
2 ) resistance to chemicals: decreased tunicamycin (6 ug/ml)[Genes (85), Intersections (10)]
92Teixeira MC, et al. (2009) Genome-wide identification of Saccharomyces cerevisiae genes required for maximal tolerance to ethanol. Appl Environ Microbiol 75(18):5761-72 PubMed
1 ) resistance to chemicals: decreased ethanol (8%)[Genes (233), Intersections (54)]
93Teixeira MC, et al. (2010) Identification of genes required for maximal tolerance to high-glucose concentrations, as those present in industrial alcoholic fermentation media, through a chemogenomics approach. OMICS 14(2):201-10 PubMed
1 ) resistance to chemicals: decreased glucose (30% (w/v)) mutant attains a lower final biomass than wild type[Genes (42), Intersections (2)]
94Thorpe GW, et al. (2004) Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes. Proc Natl Acad Sci U S A 101(17):6564-9 PubMed
1 ) Sensitive Cumene Hydroperoxide[Genes (70), Intersections (8)]
2 ) Sensitive Diamide (thiol oxidizing agent)[Genes (312), Intersections (19)]
3 ) Sensitive Hydrogen Peroxide (H2O2)[Genes (116), Intersections (15)]
4 ) Sensitive Linoleic Acid 13Hydroperoxide[Genes (115), Intersections (7)]
95Trotter EW, et al. (2006) Old yellow enzymes protect against acrolein toxicity in the yeast Saccharomyces cerevisiae. Appl Environ Microbiol 72(7):4885-92 PubMed
1 ) resistance to chemicals: decreased acrolein (5 mM)[Genes (126), Intersections (4)]
96Tucker CL and Fields S (2004) Quantitative genome-wide analysis of yeast deletion strain sensitivities to oxidative and chemical stress. Comp Funct Genomics 5(3):216-24 PubMed
1 ) Sensitive Hydrogen Peroxide[Genes (464), Intersections (52)]
2 ) Sensitive Ibuprofen[Genes (175), Intersections (53)]
3 ) Sensitive Mefloquine[Genes (172), Intersections (40)]
4 ) Sensitive Menadione[Genes (249), Intersections (57)]
97van Voorst F, et al. (2006) Genome-wide identification of genes required for growth of Saccharomyces cerevisiae under ethanol stress. Yeast 23(5):351-9 PubMed
1 ) resistance to chemicals: decreased ethanol (6%)[Genes (46), Intersections (2)]
98Viladevall L, et al. (2004) Characterization of the calcium-mediated response to alkaline stress in Saccharomyces cerevisiae. J Biol Chem 279(42):43614-24 PubMed
1 ) resistance to chemicals: decreased tacrolimus (anhydrous)[Genes (48), Intersections (17)]
99Villa-Garcia MJ, et al. (2011) Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling. Mol Genet Genomics 285(2):125-49 PubMed
1 ) auxotrophy myo-inositol[Genes (385), Intersections (5)]
100Watanabe M, et al. (2009) Comprehensive and quantitative analysis of yeast deletion mutants defective in apical and isotropic bud growth. Curr Genet 55(4):365-80 PubMed
1 ) bud morphology: abnormal bud is abnormally elongated[Genes (173), Intersections (14)]
2 ) bud morphology: abnormal bud is abnormally round[Genes (35), Intersections (2)]
101Westmoreland TJ, et al. (2009) Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae. PLoS One 4(6):e5830 PubMed
1 ) resistance to chemicals: decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin[Genes (103), Intersections (16)]
2 ) resistance to chemicals: decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin[Genes (85), Intersections (10)]
3 ) resistance to chemicals: decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin[Genes (166), Intersections (2)]
4 ) toxin resistance: decreased K. lactis zymocin|complete growth inhibition on exposure to 33% zymocin[Genes (84), Intersections (21)]
5 ) toxin resistance: decreased K. lactis zymocin|complete growth inhibition on exposure to 66% zymocin[Genes (72), Intersections (2)]
102Wilson WA, et al. (2002) Systematic identification of the genes affecting glycogen storage in the yeast Saccharomyces cerevisiae: implication of the vacuole as a determinant of glycogen level. Mol Cell Proteomics 1(3):232-42 PubMed
1 ) chemical compound accumulation: decreased glycogen[Genes (316), Intersections (24)]
2 ) chemical compound accumulation: increased glycogen[Genes (243), Intersections (9)]
103Woolstencroft RN, et al. (2006) Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length. J Cell Sci 119(Pt 24):5178-92 PubMed
1 ) resistance to chemicals: decreased hydroxyurea (100 mM)[Genes (47), Intersections (15)]
104Xia L, et al. (2007) Identification of genes required for protection from doxorubicin by a genome-wide screen in Saccharomyces cerevisiae. Cancer Res 67(23):11411-8 PubMed
1 ) gamma ray resistance: decreased gamma ray[Genes (23), Intersections (2)]
2 ) resistance to chemicals: decreased cisplatin (80 uM)[Genes (19), Intersections (5)]
3 ) resistance to chemicals: decreased daunorubicin (10 uM)[Genes (23), Intersections (3)]
4 ) resistance to chemicals: decreased doxorubicin (20 uM)[Genes (71), Intersections (5)]
5 ) resistance to chemicals: decreased hydroxyurea (80 mM)[Genes (12), Intersections (1)]
6 ) resistance to chemicals: decreased NmethylN'nitroNnitrosoguanidine (3 uM)[Genes (13), Intersections (4)]
105Yadav J, et al. (2007) A phenomics approach in yeast links proton and calcium pump function in the Golgi. Mol Biol Cell 18(4):1480-9 PubMed
1 ) metal resistance: decreased manganese(2+) (10 mM)[Genes (76), Intersections (22)]
2 ) resistance to chemicals: decreased amiodarone (10 uM)[Genes (163), Intersections (4)]
106Yoshikawa K, et al. (2009) Comprehensive phenotypic analysis for identification of genes affecting growth under ethanol stress in Saccharomyces cerevisiae. FEMS Yeast Res 9(1):32-44 PubMed
1 ) resistance to chemicals: decreased ethanol (8%)[Genes (445), Intersections (9)]
107Yoshikawa K, et al. (2011) Comprehensive phenotypic analysis of single-gene deletion and overexpression strains of Saccharomyces cerevisiae. Yeast 28(5):349-61 PubMed
1 ) vegetative growth: decreased rate nil[Genes (644), Intersections (50)]
108Zewail A, et al. (2003) Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin. Proc Natl Acad Sci U S A 100(6):3345-50 PubMed
1 ) Resistant wortmannin[Genes (586), Intersections (10)]
2 ) Sensitive wortmannin[Genes (467), Intersections (3)]
109Zhao J, et al. (2010) The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae. Genomics 95(5):290-8 PubMed
1 ) ionic stress resistance: decreased lithium(1+) (0.1 M LiCl)[Genes (38), Intersections (3)]
2 ) ionic stress resistance: decreased lithium(1+) (0.4 M LiCl)[Genes (47), Intersections (4)]
3 ) ionic stress resistance: decreased lithium(1+) (0.4 M LiCl) hypersensitive[Genes (8), Intersections (1)]
110Zhao Y, et al. (2013) Activation of calcineurin is mainly responsible for the calcium sensitivity of gene deletion mutations in the genome of budding yeast. Genomics 101(1):49-56 PubMed
1 ) resistance to chemicals: decreased calcium dichloride (0.4 M)[Genes (120), Intersections (32)]
111Zhou X, et al. (2009) A genome-wide screen in Saccharomyces cerevisiae reveals pathways affected by arsenic toxicity. Genomics 94(5):294-307 PubMed
1 ) resistance to chemicals: decreased arsenite(3-) (0.75 - 1.0 mM)[Genes (246), Intersections (6)]