Selected Tool: INTERSECTIONS TOOL

Intersection results (genes shared by multiple phenotypes)

Go to the SEARCH PHENOTYPES page and select a phenotype to re-run this tool. Alternatively select a paper from the drop-down list.
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Thorpe GW, et al. (2004) Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes. Proc Natl Acad Sci U S A 101(17):6564-9


Choose a Phenotype
Resistant Diamide (thiol oxidizing agent) [Genes (20), Intersections (0)]
Resistant Hydrogen Peroxide (H2O2) [Genes (4), Intersections (0)]
Sensitive Cumene Hydroperoxide [Genes (70), Intersections (8)]
Sensitive Diamide (thiol oxidizing agent) [Genes (312), Intersections (19)]
Sensitive Hydrogen Peroxide (H2O2) [Genes (116), Intersections (15)]
Sensitive Linoleic Acid 13Hydroperoxide [Genes (115), Intersections (7)]
Sensitive Menadione (free radical generator) [Genes (27), Intersections (0)]


There are 15 common genesets (intersecting phenotypes) for - Sensitive Hydrogen Peroxide (H2O2) (116 genes)


Intersection 1: Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
Phenotype : respiratory growth: absent glycerol carbon source (genes : 340)   p Value : 3.337e-79
Intersecting genes : ABF2, AEP1, AEP3, ATP12, ATP5, CBP3, CBS1, CBS2, CCM1, COQ1, COQ6, COQ9, COR1, CYT1, DIA4, EOS1, EUG1, EXO5, FAB1, GGC1, GLO3, GSH1, GTF1, HFI1, HMI1, HSP31, IMG1, IRC3, ISM1, LCB5, MBP1, MEF1, MEF2, MGM101, MRP10, MRP2, MRPL11, MRPL13, MRPL16, MRPL17, MRPL20, MRPL22, MRPL24, MRPL25, MRPL28, MRPL35, MRPL37, MRPL40, MRPL51, MRPL6, MRPL7, MRPS12, MRPS16, MRPS35, MRPS8, MSE1, MSF1, MSM1, MSS116, MTF1, MTF2, NAM2, PCP1, PET112, PET309, PIF1, QCR7, QCR8, RIM1, RRG7, RRG8, RSM19, RSM24, RSM25, RTC6, SLA1, SLS1, SNF2, SOV1, SSQ1, SUV3, YDL032W, YDL068W, YGR219W, YJL120W, YLR149C, YLR202C, YPR099C (genes : 88)
Intersection 2: Wilson WA, et al. (2002) Systematic identification of the genes affecting glycogen storage in the yeast Saccharomyces cerevisiae: implication of the vacuole as a determinant of glycogen level. Mol Cell Proteomics 1(3):232-42
Phenotype : chemical compound accumulation: decreased glycogen (genes : 316)   p Value : 9.11e-57
Intersecting genes : ABF2, AEP1, AEP3, ATP12, ATP5, CBP3, CBS1, CBS2, COQ9, COR1, CYT1, DIA4, EUG1, EXO5, GAL11, GGC1, GSH1, GTF1, HFI1, HMI1, HSP31, ISM1, LCB5, MBP1, MEF1, MEF2, MGM101, MRP2, MRPL11, MRPL13, MRPL17, MRPL20, MRPL22, MRPL25, MRPL28, MRPL35, MRPL37, MRPL40, MRPL51, MRPL6, MRPL7, MRPS12, MRPS16, MRPS8, MSF1, MSM1, MSS116, PAF1, PCP1, PET112, PET309, PIF1, QCR7, QCR8, RIM1, RRG8, RSM19, RSM24, RSM25, RTC6, SIN4, SLS1, SNF2, SOV1, SRB5, SSQ1, SUV3, URE2, YDL032W, YDL068W, YGR219W, YLR202C (genes : 72)
Intersection 3: Shuster A, et al. (2007) Alcohol-conferred hemolysis in yeast is a consequence of increased respiratory burden. FEMS Yeast Res 7(6):879-886
Phenotype : MACH-Slowgrowers microbial alcohol conferred hemolysis (genes : 238)   p Value : 1.007e-37
Intersecting genes : ABF2, AEP1, AEP3, ATP5, CBP3, CBS1, CBS2, CCM1, COR1, CYT1, EUG1, GTF1, HMI1, IMG1, ISM1, LCB5, MEF1, MEF2, MGM101, MRP10, MRP2, MRPL11, MRPL13, MRPL16, MRPL20, MRPL22, MRPL24, MRPL25, MRPL35, MRPL37, MRPL6, MRPL7, MRPS12, MRPS8, MSF1, MSM1, MSS116, MTF2, NAM2, PET309, PIF1, QCR8, RSM19, RSM24, SLM3, SLS1, SNF2, SOV1, SSQ1, SUV3, YDL032W, YLR202C (genes : 52)
Intersection 4: Merz S and Westermann B (2009) Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Genome Biol 10(9):R95
Phenotype : respiratory growth: absent glycerol carbon source (genes : 292)   p Value : 1.757e-36
Intersecting genes : ABF2, AEP1, ATP12, ATP5, CBP3, CBS2, CCM1, COQ1, COQ9, COR1, CYT1, DIA4, GAL11, GTF1, HFI1, HMI1, IMG1, LCB5, MBP1, MEF1, MEF2, MGM101, MRP10, MRPL13, MRPL17, MRPL20, MRPL22, MRPL24, MRPL25, MRPL37, MRPL40, MRPL6, MRPL7, MRPS16, MRPS8, MSE1, MSM1, MSS116, MTF1, MTF2, NAM2, PET112, PET309, PIF1, QCR7, RIM1, ROX3, RPE1, RRG7, RRG8, RSM19, RSM24, SLM3, SLS1, SSQ1 (genes : 55)
Intersection 5: Perrone GG, et al. (2005) Genetic and environmental factors influencing glutathione homeostasis in Saccharomyces cerevisiae. Mol Biol Cell 16(1):218-30
Phenotype : respiratory growth: absent glycerol (genes : 93)   p Value : 2.152e-35
Intersecting genes : ABF2, AEP1, ATP5, CBS1, CBS2, COQ1, DIA4, EUG1, EXO5, GLO3, HFI1, HMI1, HSP31, MEF2, MGM101, MRP2, MRPL13, MRPL22, MRPL24, MRPL28, MRPL35, MRPL6, MRPS12, MSE1, MSM1, MTF1, PET309, QCR7, QCR8, RSM19, RSM24, RSM25, RTC6, SLA1, SOV1, SSQ1 (genes : 36)
Intersection 6: Herst PM, et al. (2008) Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits. FEMS Yeast Res 8(6):897-905
Phenotype : low Plasma Membrane Electron Transport Assay for PMET (genes : 79)   p Value : 1.068e-33
Intersecting genes : CBS1, CCM1, COQ1, GGC1, GSH1, IRC3, LCB5, MRP10, MRP2, MRPL11, MRPL24, MRPL37, MRPL40, MRPL51, MRPL6, MRPL7, MRPS12, MRPS16, MSM1, MSS116, MTF1, NAM2, PET309, QCR7, QCR8, RIM1, RRG8, RSM19, RSM24, RSM25, SLS1, SNF2, YLR149C (genes : 33)
Intersection 7: Perrone GG, et al. (2005) Genetic and environmental factors influencing glutathione homeostasis in Saccharomyces cerevisiae. Mol Biol Cell 16(1):218-30
Phenotype : chemical compound excretion: increased glutathione SD medium (genes : 268)   p Value : 5.49e-28
Intersecting genes : ABF2, AEP1, ATP5, CBS1, CBS2, CCM1, COQ1, DIA4, EUG1, EXO5, FAB1, GLO3, HFI1, HMI1, HSP31, IMG1, IRC3, MEF2, MGM101, MRP2, MRPL13, MRPL22, MRPL24, MRPL28, MRPL35, MRPL51, MRPL6, MRPS12, MSE1, MSM1, MTF1, PAF1, PET309, QCR7, QCR8, RPL21A, RSM19, RSM24, RSM25, RTC6, SLA1, SLS1, SOV1, SSQ1, URE2, YPR099C (genes : 46)
Intersection 8: Tucker CL and Fields S (2004) Quantitative genome-wide analysis of yeast deletion strain sensitivities to oxidative and chemical stress. Comp Funct Genomics 5(3):216-24
Phenotype : Sensitive Hydrogen Peroxide (genes : 464)   p Value : 1.082e-23
Intersecting genes : ABF2, AEP1, ARV1, ATP5, CCC1, CGI121, COQ1, COR1, EOS1, GLO3, GND1, HFI1, HMI1, IMG1, ISM1, LCB5, MBP1, MCK1, MEF2, MGM101, MRP10, MRPL11, MRPL13, MRPL16, MRPL17, MRPL20, MRPL22, MRPL35, MRPL51, MRPL7, MRPS12, MRPS16, MRPS35, MRPS8, MSF1, MTF2, PET112, QCR7, REG1, RIM1, RPE1, RRG7, RRG8, RSM19, RTT109, SKN7, SLA1, SRB5, SSQ1, STB5, TKL1, YAP1, YDL068W (genes : 53)
Intersection 9: Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
Phenotype : mitochondrial morphology: abnormal morphology is somewhat affected; a fraction of cells exhibit wild-type mitochondrial morphology (genes : 83)   p Value : 1.16e-22
Intersecting genes : AEP1, ATP12, ATP5, CCM1, CYT1, DIA4, EUG1, EXO5, GLO3, MBP1, MEF1, MGM101, MRPL11, MRPL16, MRPL20, MRPL24, MRPL6, MRPL7, MRPS16, MSE1, MTF1, PIF1, RRG8, RSM25, SLS1, SSQ1 (genes : 26)
Intersection 10: Yoshikawa K, et al. (2011) Comprehensive phenotypic analysis of single-gene deletion and overexpression strains of Saccharomyces cerevisiae. Yeast 28(5):349-61
Phenotype : vegetative growth: decreased rate nil (genes : 644)   p Value : 4.512e-20
Intersecting genes : ABF2, AEP1, ARV1, ATP12, CBP3, CBS2, CCM1, CGI121, COQ1, COQ9, COR1, CYT1, DIA4, FAB1, GAL11, GND1, GTF1, HFI1, HMI1, LCB5, MCK1, MEF1, MGM101, MRP10, MRPL13, MRPL17, MRPL22, MRPL25, MRPL37, MRPL40, MRPL6, MRPL7, MSE1, MSM1, MSS116, MTF2, PAF1, PET112, PET309, PIF1, QCR7, RIM1, ROX3, RPL21A, RRG7, RRG8, RSM19, RSM24, SLM3, SLS1, SNF2, SSQ1, SUV3, URE2, YDL032W, YLR202C, YPR099C (genes : 57)
Intersection 11: Dilda PJ, et al. (2008) Insight into the selectivity of arsenic trioxide for acute promyelocytic leukemia cells by characterizing Saccharomyces cerevisiae deletion strains that are sensitive or resistant to the metalloid. Int J Biochem Cell Biol 40(5):1016-29
Phenotype : sensitive arsenic trioxide (genes : 341)   p Value : 1.58e-19
Intersecting genes : ARV1, CBS2, COQ6, COR1, DBF2, FAB1, GGC1, GND1, GSH1, IMG1, IRC3, LCB5, MCK1, MEF1, MRPL11, MRPL16, MRPL37, MRPL40, MRPL6, MRPS12, MSE1, MTF1, PAF1, PET309, PIF1, REG1, RPE1, RRG7, RRG8, RSM19, RSM24, RSM25, RTC6, RTT109, SKN7, SLA1, SLS1, SRB5, STB5, URE2, YAP1, YJL120W (genes : 42)
Intersection 12: McLaughlin JE, et al. (2009) A genome-wide screen in Saccharomyces cerevisiae reveals a critical role for the mitochondria in the toxicity of a trichothecene mycotoxin. Proc Natl Acad Sci U S A 106(51):21883-8
Phenotype : resistance to chemicals: increased trichothecene (4 uM) (genes : 133)   p Value : 3.397e-19
Intersecting genes : AEP1, AEP3, EXO5, FAB1, GLO3, HMI1, HSP31, IMG1, LCB5, MBP1, MEF2, MGM101, MRP10, MRP2, MRPL13, MRPL28, MRPL37, MRPL40, MRPL51, MRPL6, MSF1, MTF2, PCP1, QCR7, RIM1, RRG8, SLS1, YGR219W (genes : 28)
Intersection 13: Trotter EW, et al. (2006) Old yellow enzymes protect against acrolein toxicity in the yeast Saccharomyces cerevisiae. Appl Environ Microbiol 72(7):4885-92
Phenotype : resistance to chemicals: decreased acrolein (5 mM) (genes : 126)   p Value : 0.0000000000002204
Intersecting genes : BAP2, CGI121, COQ6, CYT1, GAL11, GLO3, GND1, MSF1, NAM2, PAF1, PET309, PIF1, QCR7, RPE1, RPL21A, SLS1, SNF2, SRB5, STB5, URE2, YAP1, YJL120W (genes : 22)
Intersection 14: Zewail A, et al. (2003) Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin. Proc Natl Acad Sci U S A 100(6):3345-50
Phenotype : Resistant wortmannin (genes : 586)   p Value : 9.032e-16
Intersecting genes : ABF2, AEP3, CBP3, CCM1, DIA4, EUG1, EXO5, GLO3, GTF1, HMI1, ISM1, LCB5, MEF1, MGM101, MRP2, MRPL11, MRPL13, MRPL17, MRPL22, MRPL25, MRPL37, MRPL6, MRPL7, MRPS12, MRPS16, MRPS35, MRPS8, MSE1, MSF1, MSM1, MSS116, MTF1, MTF2, NAM2, PCP1, PET112, PET309, PIF1, ROX3, RPL21A, RRG7, RSM19, RSM24, SLA1, SNF2, SOV1, SUV3, VPS75, YGR219W (genes : 49)
Intersection 15: Jorgensen P, et al. (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297(5580):395-400
Phenotype : cell size: decreased mutant is among the smallest 5% of haploid deletion strains (genes : 190)   p Value : 0.000000000000006495
Intersecting genes : AEP3, ATP12, CCM1, CYT1, DIA4, EUG1, GLO3, GTF1, ISM1, LCB5, MEF1, MGM101, MRPL13, MRPL17, MRPL37, MRPL51, MRPL6, MRPS35, MRPS8, MSE1, MSF1, MSM1, NAM2, PIF1, RIM1, SUV3, YGR219W, YPR099C (genes : 28)